AdDIT aims to evaluate the efficacy of ACEI and Statins in adolescents with T1D at high risk for DN and CVD, as defined by increased albumin excretion, with the major endpoint of the study being changes in albumin excretion and secondary endpoints including markers of CVD, renal function, retinopathy and early retinal microvascular changes, as well as quality of life combined with detailed assessment of compliance and likely health economic benefits. The gene discussed is ALB; the disease is retinal disorder.