IFNG and autoimmune disease: Although Th17 cells are more pathogenic in inducing autoimmune diseases than IFN-γ producing Th1 cells in mice [3,4,6], it was shown that both Th1 and Th17 cells are able to induce EAE after adaptive T cell transfer of these specific Th subsets into nude mice although Th1 and Th17 cells induced different pathology [8].