In PRIME, homozygote individuals for the minor allele of the PPARG C-689T, Pro12Ala, and C1431T SNPs tended to have a higher risk of CHD than homozygote individuals for the frequent allele (OR [95% CI] = 3.34 [0.98–11.45], P = .054, OR = 3.32 [0.97–11.39], P = .056 and OR = 5.93 [1.19–29.45], P = .029, resp). This evidence concerns the gene PPARG and coronary artery disorder.