In a double-blind placebo controlled trial 309 patients with severe, uncontrolled asthma randomized to one of 3 doses of the TNF-alpha blocking agent, golimumab administered subcutaneously (50, 100 or 200 mg) once a month or placebo, there was no significant difference in clinical efficacy between the 4 groups [64]. The gene discussed is TNF; the disease is asthma.