Symptoms will depend on the cytokine or cytokine being targeted e.g., high levels of INF-α may cause 'flu-like symptoms and anti- CD3 (muromunab) may induce cytokine release syndrome, which may include the following symptoms: flushing, arthralgias, capillary leak syndrome with pulmonary edema, encephalopathy, and severe gastrointestinal symptoms. The gene discussed is IFNA17; the disease is pulmonary edema.