TNF and cancer: A higher incidence of malignancies was found in the EMECAR database patients, which included a minority receiving TNF-alpha blocking agents, compared with the BIOBADSER registry, in which all received a TNF-alpha blocking agents there was a higher incidence of malignancy in EMECAR vs. BIOBADSER (Relative Risk (RR) 2.9) and a lower BIOBADASER by EMECAR cancer-related mortality ratio, 0.36 (0.10-1.30).