Elevated levels of total serum IgE are associated with many diseases, including allergic bronchopulmonary aspergillosis (ABPA), parasitosis, atopic dermatitis, adult HIV infection, hyper-IgE (Job's) syndrome, Sézary's syndrome, IgE myeloma, and Kimura's disease[1]. The gene discussed is IGHE; the disease is parasitic infectious disease.