Modestly elevated IgE has also been reported in B-cell chronic lymphocytic leukemia[11] and in 2 patients with Hodgkin's disease (1 case of nodular sclerosing, one case of mixed cellularity, levels were 675 IU/mL and 310 IU/mL, respectively)[12]. The gene discussed is IGHE; the disease is B-cell chronic lymphocytic leukemia.