Although we did not find the COX-2 926G>C SNP to be a prognostic marker for NSCLC, NSCLC patients with the GC or CC genotype were apparently more susceptible to lymph node metastases and higher tumor stage than patients with the GG genotype, suggesting that the COX-2 926G>C SNP is a molecular marker for lymph node involvement. The gene discussed is PTGS2; the disease is non-small cell lung carcinoma.