In breast cancer, the COX-2 169-GG genotype was associated with increased risk [47], but the COX-2 926G>C SNP was not [48], while some tenuous evidence was found for an interaction between the C allele of the COX-2 8473 SNP with NSAIDs to reduce risk for hormone receptor positive breast cancer. This evidence concerns the gene NR4A1 and breast carcinoma.