Although the detailed histological and hypothesis-based molecular analysis implicated the pivotal role of prostaglandin E2, Wnt and Nog pathway respectively in gastric tumorigenesis, it remains elusive whether the K19-C2mE and its compound transgenic mice show similarity to intestinal type or diffuse type of human gastric cancers when analyzed by non-biased global expression profile. The gene discussed is KRT19; the disease is gastric cancer.