In the case of MYOC-associated POAG, the aggregates induced the unfolded protein response proteins BiP and phosphorylated endoplasmic reticulum-localized eukaryotic initiation factor-2_ kinase (PERK) with the subsequent activation of caspases 12 and 3 and expression of C/EBP homologous protein (CHOP)/GADD153, leading to abnormal HTM cell morphology and cell apoptosis[24,28]. The gene discussed is MYOC; the disease is open-angle glaucoma.