In human CRCC, we show, using various experimental approaches, i.e cyclopamine, Smo and Gli1 targeting siRNAs and Smo and Gli1 overexpression, that the SHH signaling pathway stimulates essentially cell proliferation and in a lesser degree inhibits cell death, and no effects were observed on tumor cell senescence. This evidence concerns the gene SHH and chromophobe renal cell carcinoma.