ACVR2A and malignant colon neoplasm: To study whether epigenetic changes are associated with ACVR2 expression loss, we assessed whether the ACVR2 promoter was hypermethylated in colon cancer tissue as compared to normal and if so, whether a specific methylation pattern of ACVR2 correlated with ACVR2 protein loss in primary MSS colon cancer specimens.