We then performed genomic subtype analysis of all ACVR2 non–expressing cancers and found that the lack of the chromosomal instability (CIN) phenotype correlated with ACVR2 promoter hypermethylation (Table 2), suggesting separate pathways for MSI-/LOH+ and MSI-/LOH- colon cancers. Here, ACVR2A is linked to malignant colon neoplasm.