Our experiments demonstrated potent cytoxicity of EA in primary CLL cells with IC50 of 8.56+/−3 μM, while the IC50 for EA inhibition of Wnt3A-induced transcription in HEK293 is about 25 μM, and the EA concentration required to destabilize the LEF-1/β-catenin complex is at least 60 μM. The gene discussed is LEF1; the disease is B-cell chronic lymphocytic leukemia.