Unexpectedly, we found that hif-1(ia04) loss-of-function mutant animals as well as egl-9(sa307) hif-1(ia04) mutant animals are resistant to P. aeruginosa PA14 infection, heat stress, and oxidative stress (Figure 4E, Table 2; Figures 4F and 4G). The gene discussed is HIF1A; the disease is infection.