Analysis of the 1958 British Birth Cohort revealed a lower risk for metabolic syndrome in subjects with the highest tertiles of both serum 25(OH)D and IGF-1 concentrations, although there was no statistical interaction between 25(OH)D and IGF-1 in any of the individual components of the metabolic syndrome and HbA1c [64]. This evidence concerns the gene IGF1 and metabolic syndrome.