MDR1/PgP acts as a glycolipid translocase involved in the biosynthesis of glycolipids such as Gb3, and elevated levels of Gb3 have also been seen in drug-resistant cancers, and functional interplay between membrane Gb3 and MDR1/PgP has been suggested (Lingwood et al, 1998; De Rosa et al, 2008). The gene discussed is PGP; the disease is cancer.