However, our data show that, in breast cancer cells, CDK2 depletion resulted in G1 accumulation, and a reduction in the S-phase fractions in both tamoxifen-sensitive MCF7 and T47D cells, and resistant LCC9 and HCC1937 cells, indicating that CDK2 knockdown or inhibition may not be as easily compensated in all cell types, and may have an important role in G1 progression in breast cancer cells compared with other types of cancer cells. The gene discussed is CDK2; the disease is cancer.