Lack of association between ACE I/D polymorphism and essential hypertension have been reported by investigators in Indian and other populations of the world.[25–28, 40] Ethnic background is known to influence the ACE I/D polymorphism globally.[29, 30] A significant association of the ACE high producing D allele with hypertension in African, Americans, Chinese, and Japanese populations have already been reported.[8, 22–24] However, two studies from Australia[31] and Pakistan[32] recorded the association of I allele with hypertension. This evidence concerns the gene ACE and Hypertension.