NFKB1 and cancer: It is worth mentioning that alterations in GO categories related to "negative regulation of cell proliferation", "cell cycle", "positive regulation of I-κB kinase/NF-κB cascade" and "induction of apoptosis" correlated very well with existing experimental evidence supporting that mastic oil causes regression of tumor growth by inhibiting cancer cell proliferation and survival [13,16,17], reducing tumor-associated expression of inflammatory mediators [17] and down-regulating NF-κB transcriptional activity [14,17].