It has been reported that transfection of the sense cDNA of N-acetylglucosaminyltransferase(GnT)-V, an enzyme associated with cancer progression and metastasis, into human H7721 hepatocarcinoma cells resulted in an increase in the level of GlcNAcβ1,6 Manα1,6-branch (GnT-V product) on the N-glycans of EGFR, this promoted the tyrosine autophosphorylation of EGFR [40]. The gene discussed is EGFR; the disease is cancer.