TNFSF10 and melanoma: Sensitization of fresh melanoma isolates to TRAIL-induced apoptosis by 2-DG was substantially inhibited by a recombinant TRAIL-R2/Fc chimera (p < 0.05) (Figure 7D), indicating that the effect of 2-DG on TRAIL-induced apoptosis in fresh melanoma isolates is largely accounted for by the increase in TRAIL-R2 expression on the cell surface.