Nevertheless, the classic ER stress inducers, the glycosylation inhibitor TM and the ER Ca2+ ATPases inhibitor TG have been shown to enhance TRAIL-induced apoptosis in melanoma cells by up-regulation of TRAIL-R2 via activation of the UPR [29,30], but these compounds are not clinically applicable due to their toxicity towards normal tissues. The gene discussed is TNFRSF10B; the disease is melanoma.