We have previously shown that, although melanoma cells are not sensitive to ER stress-induced apoptosis, activation of the UPR by the glycosylation inhibitor tunicamycin (TM), or the ER Ca2+ ATPases inhibitor thapsigargin (TG), up-regulates TRAIL-R2 and enhances TRAIL-induced apoptosis in melanoma cells [28-30]. Here, TNFSF10 is linked to melanoma.