TCOF1 and Treacher-Collins syndrome: Although the number of tested individuals was smaller, we also detected a significantly lower expression of TCOF1 in TCS patients (~31%; Figure 2; patients mean ± SEM = 0.9687 ± 0.1122; controls mean ± SEM = 1.414 ± 0.09010; p = 0.0213; Two-tailed unpaired t test with Welch's correction).