In the present study, we describe a case-control study of lung adenocarcinoma in non-smoking female population in Shenyang, China, to evaluate the roles of the SNPs in ERCC1 and ERCC2 gene on risk of lung adenocarcinoma and explore the interaction between genetic polymorphism and exposure to environmental risk factors in the development of lung adenocarcinoma. This evidence concerns the gene ERCC2 and lung adenocarcinoma.