Multivariate analysis using Cox' s proportional hazard model indicated that age, depth of invasion, lymphatic invasion, lymph node metastasis, Lauren's classification and mTOR expression (p < 0.05), but not sex, tumor size, UICC staging, cytoplasmic or nuclear P70S6K expression were independent prognostic factors for overall gastric carcinomas (p > 0.05, Table 7). The gene discussed is RPS6KB1; the disease is gastric carcinoma.