TNFSF13 and colorectal adenocarcinoma: The biological function of APRIL as a secreted molecule that has autocrine and paracrine functions to promote cell survival and proliferation and its previously documented expression in colorectal adenocarcinoma but not normal cells outside the immune system, supported it's further investigation as a novel mechanism of 5FU action and resistance, and as a predictive biomarker [15-19,31-35].