However, in vitro work in glioma cell lines and ex vivo studies in BCLL, has shown that APRIL stimulates proliferation and inhibits apoptosis in response to a wide range of stimuli, including CD95L, TRAIL and cytotoxic drugs and survival in B-CLL cells involves NFκB activation [15-19,31-34]. Here, NFKB1 is linked to central nervous system cancer.