Our current data confirm this model-specific dependence on divergent cytokine profiles, as administration of either anti-IL-1 or anti-TNFα in CIA significantly decreased local indices of arthritis (paw swelling and leukocyte infiltration), while anti-IL-1 had no effect on local inflammation and anti-TNFα significantly reduced only paw swelling in AIA (Figures 1 and 2, and Table 1). The gene discussed is TNF; the disease is Arthritis.