Some genes as TAF5L, TFCP2L4, PHF20, LMO4, TCF20 and RFX2 that were known to have transcription factor activities express highly in SCLC[16] but the genes that were upregulated by HIF-1 alpha are TRIM22, IRF9, MYOCD, ZNF277 and CREM from our study. Here, CREM is linked to small cell lung carcinoma.