Here we present an analysis of DAE in 12 candidate genes (BRCA1, BRCA2, C1qA, CCND3, EMSY, GPX1, GPX4, MLH3, MTHFR, NBS1, TP53 and TRXR2) likely to be involved in breast cancer, in a large set of individuals. This evidence concerns the gene BRCA2 and breast carcinoma.