Here we present an analysis of DAE in 12 candidate genes (BRCA1, BRCA2, C1qA, CCND3, EMSY, GPX1, GPX4, MLH3, MTHFR, NBS1, TP53 and TRXR2) likely to be involved in breast cancer, in a large set of individuals. The gene discussed is C1QA; the disease is breast cancer.