Recent data, however, indicate that intensive insulin therapy does not have a beneficial effect in critically ill patients and that it increases the risk of serious adverse events related to hypoglycemia; in the Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation (NICE-SUGAR) study it was found that intensive glucose control increases mortality among patients treated in the intensive care unit [5,6]. The gene discussed is INS; the disease is Hypoglycemia.