HIF1A and cervical carcinoma: We have generated a HRE-bla line in ME 180 cells, human cervical cancer cells, by isolating a clonal cell line that responds to hypoxic conditions by up-regulating β-lactamase expression after fluorescence-activated cell sorting (FACS) of cells in response to treatment with deferoxamine (DFO), a known inducer of HIF-1 [20].