Recently, a common polymorphism located at intron 2 (rs4149601) of the NEDD4L gene was shown to be associated with hypertension both in African Americans and Caucasians, and a "flip-flop" association with hypertension was found in two Caucasian samples [10] for a common polymorphism located at intron 12 (rs3865418). Here, NEDD4L is linked to hypertensive disorder.