In this study, we sequenced the promoter and all exons of NEDD4L in 94 Xinjiang Kazakh hypertensive individuals to identify common single nucleotide polymorphisms (SNPs) and rare variations, and then genotyped the representative variations in the general population to systemically study whether genetic variations in NEDD4L are implicated in essential hypertension in the Xinjiang Kazakh general population. This evidence concerns the gene NEDD4L and essential hypertension.