Regarding the mechanisms by which two common SNPs (296921-296923delTTG and rs2288775) might contribute to essential hypertension in only females, it has been reported that NEDD4L expression is down-regulated in prostate cancer and up-regulated following androgen treatment [27,28], suggesting that the variations of NEDD4L are associated with androgen-mediated gender differences in essential hypertension. This evidence concerns the gene NEDD4L and essential hypertension.