Rs4149601 (16229 bps from exon 2) of NEDD4L is associated with hypertension in African Americans and Caucasians and rs3865418 (4106 bps from exon 13) has been shown to have a "flip-flop" association with hypertension in two Caucasian samples [10]. The gene discussed is NEDD4L; the disease is Hypertension.