This process has been directly implicated in genetic studies of motor neuron diseases (GARS[40], [41], YARS[42] and IARS[43] genes), and the RNA processing pathway in general is involved in amyotrophic lateral sclerosis as evidenced by ALS-linked mutations identified in the SETX, FUS and TARDBP genes[5]–[7], [11]–[13], and the association of ALS with variants in the ANG[18]–[22] and ELP3[44] genes. The gene discussed is SETX; the disease is motor neuron disorder.