Three further loci that were identified as showing significant association with ALS in this study were also identified as significantly associated with ALS by Cronin and colleagues[28]: the chromosome 5 locus flanking HCN1, the chromosome 8 locus flanking POTE8 and the chromosome 11 locus including OR4A5 and flanking OR4C12 (this locus was lost from our region-based approach upon conversion of genome coordinates to build 36, see table S1). This evidence concerns the gene OR4C12 and amyotrophic lateral sclerosis.