APOE and nervous system disorder: Novel neuroprotectors, known as mimetics of apolipoprotein E (apoE), block neurodegeneration and restore cognitive functions in transgenic Drosophila. Selection of apoE-mimetics derived from the receptor-binding region of apoE was based on the ability of these peptides to mimic the functional anti-inflammatory and neuroprotective effects of the intact apoE protein seen in different animal models of neurological diseases [21], [22].