Although we cannot exclude with certainty the role of t-Ag and other T'- proteins, based upon our results it is reasonable to speculate that T-Ag may be the primary mediator of a metastatic phenotype in colon cancer cells, and some of these effects may directly or indirectly be influenced by the activation of AKT/MAPK pathways [44], [45]. The gene discussed is AKT1; the disease is malignant colon neoplasm.