Our findings are also consistent with the analysis of genes which are differentially expressed in response to MYCN over expression in NB cell lines, where the CATGTG motif was identified in the promoter regions of 95/139 differentially expressed genes (68%) compared to the CACGTG motif which was detected in promoter regions of 41/139 genes (29%) [4]. The gene discussed is MYCN; the disease is neuroblastoma.