Significant tumor-specific demethylation was found in MAGEA3 (p<0.005), MAGEA12 (p<0.025), MAGEA4 (p<0.018), MAGEA1 (p<0.001), TKTL1 (p<0.025) and MAGEA5 (p<0.007). This evidence concerns the gene TKTL1 and neoplasm.