Since treatment with either VEGF antagonists [5], [9], [10] or PDGF antagonists [6], [11], [12] have been found to lower tumor IFP, and in view of the potential clinical utility of lowering tumor IFP to enhance chemotherapy, we investigated if the combination of anti-VEGF and anti-PDGF treatment gives a synergistic lowering effect on tumor IFP. Here, VEGFA is linked to neoplasm.