β-catenin has been identified as an important hub which interacts with significant genes such as GSK-3B, CDH5, SMAD and TGFBRI. The network, named as Wnt_VascularComplication (Figure 5A) summarizes a network flow of genes involved in these pathways, which further correlates with the significant clinical observations in diabetes subjects. Here, GSK3B is linked to diabetes mellitus.