The TranscriptionFactors_KidneyComplication sub-sub-network observed from diabetes, obesity and PCOD datasets suggests a common pathway for causing impaired insulin signalling and generating vascular complications through the interaction between pathways mediated by growth related proto-oncogenes and GCR. The sub-network illustrates that increased FFA linked with GCR plays a pivotal role in progression of T2D. This evidence concerns the gene NR3C1 and obesity due to melanocortin 4 receptor deficiency.