Of special interest were human promyelocytic leukaemia (HL60) cells, which were fully competent for CagA translocation (Figure 1A, lanes 1–3 and 7), whereas, HL60 cells differentiated to a granulocyte-like phenotype (dHL60 cells) revealed only a very weak CagA-P signal (Figure 1A, lanes 4–6 and 8). The gene discussed is S100A8; the disease is acute promyelocytic leukemia.