CD8A and tropical spastic paraparesis: Since high frequency of CD45RA−CD27+ memory CD8+ T cells and high proliferation rate of CD8+ CD45RO+ T cells have been reported in patients with HAM/TSP [10],[60] and in HTLV-I-infected patients (both ACs and patients with HAM/TSP [61]), the expression of CD244 on CD8+ T cells in HTLV-I-infected patients is consistent with the interpretation that CD244 is a marker of memory CD8+ T cells and with persistent immune activation in HTLV-I-infected patients.