EGFR and malignant colon neoplasm: Although IHC analysis of EGFR in colon cancers does not predict the efficacy of anti-EGFR antibody therapy (Ciardiello and Tortora, 2003; Chung et al, 2005; Van Cutsem et al, 2007), the potential predictive impact of phospho-EGFR expression for anti-EGFR antibodies in human colorectal cancers remains unknown.