CCND1 and colorectal carcinoma: ERK translocates to the nucleus and phosphorylates transcription factors that regulate genes controlling cell proliferation, including cyclin D1 (Cesana et al, 2006) that is overexpressed in 30–50% of colorectal carcinomas and is associated with a poor prognosis (Arber et al, 1996; McKay et al, 2000).