MRC1 and neoplasm: Tumours with defective MMR were significantly more likely to show proximal location, poor/undifferentiated histology, and to be from older aged patients compared to cases with intact MMR (data not shown), as previously reported (Lothe et al, 1993; Thibodeau et al, 1993, 1998; Halling et al, 1999; Gryfe et al, 2000; Sinicrope et al, 2006a, 2006b).