PGR and neoplasm: In our analysis, CUL4A overexpressing tumors were characterized by a high histological grade, an absence of PR and BCL2 expression, and a high expression of cell cycle promoters (cyclin B and SKP2), cell signaling components (EGFR), basal cytokeratins (CK5), and cell adhesion proteins (P-cadherin) (Table 4), suggesting high cell proliferation and tumor aggressiveness.