Multiple regression analyses (performed in the SCD group as a whole with 3-year cumulative hospitalizations as the dependent variable, and hs-CRP, sP-selectin, VCAM-1, LDH, WBC and HbF as the independent variables) identified associations only with hs-CRP and WBC which contributed 22% and 5% respectively, to the overall model. The gene discussed is VCAM1; the disease is Schnyder corneal dystrophy.