ZBTB16 and neoplasm: Increased expression of Txnip and Zbtb16 expression by CR could reflect an anti-proliferative effect of low calorie diets on a common pathway, since Txnip encodes a protein known to induce expression of Zbtb16 [41], and both genes encode proteins that can promote apoptosis or limit the invasive capacity of tumor cells [28,41,42].