The disease is transmitted by perinatal, parenteral, sexual routes.(1) Healthcare workers, particularly surgeons, pathologists, dentists and physicians working in hemodialysis and oncology units, are at a higher risk of contracting HBV infection via minor skin cuts and accidental needle punctures.(2) Since proper vaccination can prevent HBV infection, complete hepatitis B vaccination is necessary for medical and paramedical students. This evidence concerns the gene PPIB and hepatitis A virus infection.