In order to evaluate whether polysaccharide-containing macromolecules in TJ-41 contribute to expression of enhancing activity on upper respiratory mucosal immune system of TJ-41, each of F-1–F-5 obtained from TJ-41, was orally administered at doses related to their yields from TJ-41 to young or early aged BALB/c mice, which were nasally immunized twice with influenza vaccine, and titers of influenza virus specific IgG or IgA antibody were measured for sera or nasal washes from the mice, respectively. The gene discussed is CD79A; the disease is influenza.