INS and Hyperglycemia: This proposal covers a new concept for the natural history of T1ADM which, in its preclinical stage, would be characterized by a succession of relapses and remissions with interrelation between regulatory T cells (T-regs) and effectors cells, and regeneration of beta cells up to the moment when the percentage of beta cell destruction would no longer allow a proper insulin secretion, resulting in the expression of hyperglycemia.