MMP14 and neoplasm: Membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14), the best characterized membrane-anchored MMP, plays essential roles in tumor cell migration and invasion by acting as a potent matrix-degrading protease that digests a broad spectrum of ECM proteins [13-15] as well as a number of cell surface-associated adhesion receptors [16,17].