Of note, PML (promyelocytic leukemia) bodies are sub-nuclear compartments that have been shown by certain groups to inhibit HIV-1 through different mechanisms: (i) by modulating the availability of essential transcription cofactors such as CyclinT1 [277], thereby regulating Tat-mediated transcriptional trans-activation; (ii) by triggering the exportin-mediated cytoplasmic export of the Ini1 subunit of the SWI/SNF complex in association with PML proteins [278]. The gene discussed is PML; the disease is acute promyelocytic leukemia.