With the aim to investigate the involvement of adiponectin in angiogenesis in B-CLL, we have assessed serum levels of adiponectin in 69 patients with Binet stage A CLL, and these values were retrospectively correlated with bone marrow microvessels area and serum levels of VEGF, FGF-2, angiogenin, PECAM-1 (CD31), MMP-9, interleukin-8 (IL-8), syndecan-1, and the percentage of CD38+ or ZAP-70+ CLL cells. This evidence concerns the gene ANG and B-cell chronic lymphocytic leukemia.