Significantly, F-Ade inhibits proliferation of a variety of cell types including the murine colon carcinoma CT26 or CT26HER2/neu and the human breast cancer line MCF7-HER2, as well as melanoma tumor cell line, B16 and murine B-cell tumor cells, 38C13 (data not shown). This evidence concerns the gene ERBB2 and breast carcinoma.