We have used these four cell lines since they represent a wide spectrum of b-cell lineage tumors: (a) WSU-FSCCL [representing follicular low grade non-Hodgkin's lymphoma type that is wt-p53]; (b) WSU-WM [representing plasmacytoid type that is mut-p53]; (c) RL representing diffuse large B-cell lymphoma, mut-p53; (d) WSU-DLCL2 [representing diffuse, Intermediate grade non-Hodgkin's lymphoma mut-p53]. This evidence concerns the gene TP53 and non-Hodgkin lymphoma.