MDM2 and neoplasm: Data obtained in our studies is encouraging and is consistent with the following statements: i) MI-319 is able to bind to MDM2 protein with a high affinity that is over 500-fold more potent than a natural p53 peptide; ii) MI-319 effectively inhibited proliferation of FSCCL cell (p53 wild-type) in vitro, with IC50 value of 2.5 μM for 48-hour treatment; iii) Inhibition of FSCCL cell proliferation by MI-319 involves induction of both cell cycle arrest and apoptotic death; iv) MI-319 displayed potent anti-tumor efficacy in the FSCCL-SCID mouse model.